Event to celebrate new GW4 high-resolution cryo Electron Microscope for structural biology
Cryo Electron Microscopy has recently undergone a “resolution revolution” allowing imaging at near-atomic resolution for single-particle analysis of large multi-subunit assemblies and cryo-tomography of frozen hydrated samples, cell organelles and cells in its native state.
Following an award made by the Wellcome Trust to Prof Christiane Schaffitzel and a team of researchers across our GW4 partners we will be establishing a dedicated Cryo-EM Facility for structural biology at the University of Bristol. The Facility that will become part of the Electron Microscopy unit of the Wolfson Bioimaging Facility headed by Prof Paul Verkade, School of Biochemistry, and will be housed in the basement of the Life Sciences Building.
There it will become part of a suite of microscopy and analysis tools. The cryo EM, which will be equipped with automated acquisition software and sample exchange using an autoloader system is also co-funded by the GW4 Alliance and made possible by a significant investment for refurbishment by the University of Bristol amounting to an overall investment of £2.3M. Following the refurbishment and installation of the microscope early next year we expect to be fully operational by summer 2017.
Opening Ceremony of the GW4 Facility for High-Resolution Electron Cryo-Microscopy
13:00 Opening Address
Session 1, chaired by Christiane Berger-Schaffitzel
13:20 – 14:30 Sjors Scheres, LMB Cambridge
The atomic structure of Tau filaments from Alzheimer’s disease brain
14:30 – 14:50 Ariel Blocker, University of Bristol
Structure, assembly and function of the “injection needle” and “tip” of type III secretion machines
14:50 – 15:10 Bertram Daum, University of Exeter:
CryoEM in Exeter – focus on the structure and function of the type-IV plus machinery in bacteria and archaea
Coffee Break & Poster Session
Session 2, chaired by Paul Verkade
15:45 – 16:05 Danielle Paul, University of Bristol
Relaxed and active structures of the thin filament: a new structural mechanism for the regulatory mechanism
16:05 – 16:55 John Briggs, LMB Cambridge/ EMBL Heidelberg
Cryo-electron tomography: a tool for “in situ” structural biology to study molecular assembly mechanisms of HIV
16:55 – 17:00 Closing Address
Drinks & Poster Session
For further information contact Dr Sarah Perkins, GW4 Director.