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Isoform-level psychiatric genomics

The underlying biology responsible for schizophrenia, autism, and related disorders receives substantial contribution from heritable genetic mutations. Understanding the specific effects of these mutations across tissues and developmental stages is key to designing new medications. Across GW4 there is strong expertise in psychiatric genomics and the use of novel long-read sequencing methods. This award will fund a workshop in Spring 2024 to bring this expertise together in order to improve the understanding of the effects of causal genetic variants which will lead to a greater understanding of disease mechanisms critical for informing drug development.

University of Bath
University of Bristol
Cardiff University
University of Exeter