GW4 Supercomputer Isambard
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- Tier 2 high performance computing service for UK-based scientists.
- Provides multiple advanced architectures within the same system
- Enables direct ‘apples-to-apples’ comparisons across architectures
- Collaboration between the GW4 Alliance, Cray Inc., and the Met Office.
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Professor Simon McIntosh-Smith, PI for the Isambard project
isambard-support@gw4.ac.uk
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VSimulators
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- Multidisciplinary human factors research facility
- Motion platform and motion capture technology
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Exeter Science Park
vsimulators@exeter.ac.uk
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GW4 Shared Scanners
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- Pre-clinical In-vivo Functional Imaging for Translational Regenerative Medicine Platform
- Multi-photon Microscope (zebra fish & rodent)
- Micro PET/CT scanner
- 3T large animal MRI scanner
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Multi-photon Microscope (Bristol)
Micro PET/CT scanner (Cardiff)
3T large animal MRI scanner (Bristol)
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GW4 Facility for High-Resolution Cryo-Microscopy (GW4 Cryo-EM Facility)
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Microscopy and Analysis for cell function or malfunction
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Prof Christiane Berger-Schaffitzel
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Exeter Centre for Cytomics
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- Advanced Multiparameter Cytometry
- Full Spectral Flow Cytometry
- Quantitative Imaging Flow Cytometry
- Single Cell Genomic Cytometry
- Fluorescence Activated Cell Sorting (FACS)
- Luminex Multiplexing Assays
- Complex Data Analysis (ML/AI)
- Specialized Cytometry Training
- Industrial/CRO conform Assays
- Collaborations on Basic- & Applied Research
- Consultancy
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Dr Raif Yuecel & Dr Attila Bebes
cytometry@exeter.ac.uk
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GW4 Facility for High-Resolution Electron Cryo-Microscopy
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- Single Particle Analysis
- Cryotomography
- Suitable for Structural Biology and Soft Matter Nanomaterials
- 200 kV X-FEG for generation of highly coherent electron beam
- GATAN K2 Direct Electron Detector with Counting Mode capability and Zero Loss Peak energy filtering for high-resolution images
- On-the-fly processing for monitoring and optimisation of data collection parameters
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gw4-cryoem@bristol.ac.uk
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Wales Positron Emission Tomography Imaging Centre (PETIC)
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- Clinical and Pre Clinical Services
- FLT, FDG, FDOPA, Fallypride, Beta amyloid & Tau imaging
- FDOPA and Fallypride quantification of dopaminergic transport and receptor function
- NaF bone scanning
- Gallium 68 DOTANOC imaging for neuroendocrine tumours
- F Choline PET in Prostate Cancer
- Monoclonal antibody imaging and kinetics
- Stem Cell tracking
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Chris Marshall
PETIC@cardiff.ac.uk
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Exeter Offshore testing facility
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- FaBTest has unique pre-consent for device demonstration
- Full site survey and resource characteristics available
- Test whole systems, sub-systems or numerical models
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Lars Johanning
l.johanning@exeter.ac.uk
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Exeter Centre for Graphene Science
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- Graphene related device manufacture
- Thin film deposition
- E-beam lithography
- Laserwriting
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Mark Heath
m.heath@exeter.ac.uk
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Exeter Biosciences Sequencing facility
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- High throughput library preparation
- Long read sequencing
- Reduced representation sequencing (e.g. RAD-seq)
- Amplicon sequencing
- 16S/18S profiling
- Denovo genome assembly
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Konrad Paszkiewicz
biosciences-sequencing@exeter.ac.uk
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Cardiff X-ray Photoelectron Spectroscopy (XPS) analysis
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David Morgan
MorganDJ3@cardiff.ac.uk
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Cardiff Transmission Electron Microscope
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- 3D tomography with high-stability goniometer stage
- EDS elemental analysis with elemental mapping and line scan capability
- CRYO imaging at -175 oC
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Mahmoud Akhtar
akhtarm@cardiff.ac.uk
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Cardiff Single Crystal X-ray diffraction
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- Dual wavelength, single crystal diffraction
- Variable temperature diffraction measurements (80-500K)
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Mahmoud Akhtar
akhtarm@cardiff.ac.uk
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Cardiff Scanning Electron Microscope
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- EBSD
- EDX
- SE, BS, STEM imaging
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Mahmoud Akhtar
akhtarm@cardiff.ac.uk
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Cardiff Powder X-ray diffraction
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- Variable temperature/room temperature powder X-ray diffraction measurements (16-300K)
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Mahmoud Akhtar
akhtarm@cardiff.ac.uk
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Cardiff Nuclear magnetic resonance
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- Acquisition of Small molecule and Biological molecule NMR data
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Mahmoud Akhtar
akhtarm@cardiff.ac.uk
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Cardiff Mass spectrometry and chromatography
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- Generation of High Res and Low Res Mass Spectrometry data
- HR GCMS, HR and LR LCMS, ICPMS
- Quantitative determination of metals in solution/solids
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Mahmoud Akhtar
akhtarm@cardiff.ac.uk
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Cardiff Gas Turbine Research Centre
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- Gas Analysis, NOx, CO, THC, O2, NH3
- Particulates, LII, DMS
- Laser diagnostics, LDA, PDA, PIV, PLIF
- Chemiluminescence
- High-Speed Videography
- High-Fidelity Combustion Dynamics
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Steve Morris
MorrisSM@cardiff.ac.uk
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Cardiff Central Biotechnology Services (CBS)
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- Gene expression profiling
- SNP genotyping and copy number analysis
- MicroRNA analysis and methylation analysis
- Evaluation of RNA quality
- Large scale RT-PCR and TLDAs
- Bioinformatics analysis
- Primer and Project design and data analysis
- Electrochemiluminescence
- Flow Cytometry and cell sorting
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Charlotte James
CBSadmin@cardiff.ac.uk
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Cardiff Bioimaging Research Hub
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- Histological sample processing and slide preparation service
- Full training and support on all imaging systems
- Confocal laser scanning microscopy with airyscanning technology, FLIM and FCS
- Automated, high throughput, multiformat imaging with widefield, confocal and airyscan modalities
- Spinning disc confocal microscopy
- Lightsheet microscopy
- In vivo fluorescence and bioluminescence imaging
- Live cell imaging
- Laser microdissection
- Microfluorimetry
- Conventional light microscopy (brightfield, darkfield, phase contrast, DIC, polarising, fluorescence, reflectance microscopy)
- Whole slide imaging
- Stereomicroscopy, microimaging and digital photography
- Advanced image processing and analysis with machine learning
- 3D printing service
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Anthony Hayes (Facility manager) or Pete Watson (Academic lead for imaging)
bioimaginghub@cardiff.ac.uk
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Bristol X-ray Analytical Service
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- Single crystal X-ray structure determination (90-400K)
- Variable temperature/room temperature powder X-ray diffraction measurements (16-300K)
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Hazel Sparkes
hazel.sparkes@bristol.ac.uk
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Bristol Wolfson Bioimaging Facility
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- Latest-state-of-the-art Light and Electron Microscopy
- Correlative Light Electron Microscopy (CLEM)
- Cell & life sciences imaging for biological and biomedical research
- Sample processing
- Image analysis support
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Mark Jepson
m.a.jepson@bristol.ac.uk
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Bristol Translational Biomedical Research Centre (TBRC)
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- Full medical, surgical and drug research on large animal models
- High resolution MRI and surgical examination
- Onsite anaesthetist
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Stuart Pope
tbrc@bristol.ac.uk
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Bristol Proteomics Facility
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- Protein Separation
- Protein identification
- Quantitative Proteomics (SILAC, TMT)
- Phosphoproteomics
- Serum Proteomics
- Identification of protein binding partners
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Kate Heesom
k.heesom@bristol.ac.uk
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Bristol MRC Integrative Epidemiology Unit Metabolomics NMR Facility
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- Quantitative, low volume metabolic measurement of human serum/EDTA-plasma
- Metabolite profiling
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Matt Goodwin
bristol-metabolomics@bristol.ac.uk
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Interface Analysis Centre (IAC)
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- Materials analysis
- Facilities for the handling and analysis of radioactive specimens
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Keith Hallam
k.r.hallam@bristol.ac.uk
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Bristol Histology Services
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- Complete histological service
- Fresh, fixed & frozen sectioning and staining
- Wax processing
- Immunocytochemistry & immunofluorencent staining
- Image capture
- Consultancy
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Debbie Martin
debbie.martin@bristol.ac.uk
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Bristol Electron Microbeam Laboratories
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- Quantitative X-ray microanalysis
- X-ray mapping
- Scanning electron microscopy and CL imaging
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Stuart Kearns
Stuart.Kearns@bristol.ac.uk
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Bristol Clinical Research and Imaging Centre (CRICBristol)
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- Siemens 3 Tesla MRI scanner and sleep laboratories
- Studies in healthy volunteers and clinical populations
- Full technical and training support
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cric-contact@bristol.ac.uk
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Bristol Chemical NMR Facility
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- Solution state Nuclear Magnetic Resonance spectrometry of small molecules
- Multinuclear and diffusion NMR
- Molecular structure and mixture analysis
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Craig Butts
Craig.Butts@bristol.ac.uk
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Bristol Chemical Mass Spectrometry Facility
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- HPLC-MS/UPLC-MS
- LC-MSn
- Nano-LC-MS
- IMS-MS
- Accurate mass, EI, CI, ESI, nanospray and MALDI MS
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Paul Gates
Paul.Gates@bristol.ac.uk
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Bristol Chemical Imaging Facility
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- Fully-supported TEM
- Range of sample holders and detectors for materials analysis
- Fully-supported AFM installed in Cat 2 lab
- Experiment design, sample preparation, image/spectra acquisition, data analysis
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Sean Davis
S.A.Davis@bristol.ac.uk
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Bristol Genomics Facility
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- Next generation sequencing
- Microarray expression analysis
- High throughput Genotyping
- Real-time quantitative PCR
- Capillary sequencing and genotyping
- DNA and RNA analysis and quality assessment
- Bioinformatic support
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Jane Coghill or Christy Waterfall
genomics-facility@bristol.ac.uk
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Bath Nanofabrication facility
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- Access to the facility to carry out own processing
- Safety and equipment training and support is provided
- Technical support for some sample fabrication
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Stephen Wedge
nanofab@bath.ac.uk
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Bath Microscopy and analysis suite
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- Full image analysis
- Light, scanning probe and electron microscopy
- Full service package
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Ursula Potter
U.J.Potter@bath.ac.uk
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Bath Material and Chemical Characterisation Facility (MC²)
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- Electron microscopy (SEM, TEM and cryo-FE-SEM)
- Mass spectrometry coupled to gas- and liquid chromatography
- Bio-imaging confocal microscopy and cell analysis
- X-ray diffraction (Powder and single crystal)
- Nuclear magnetic resonance spectroscopy (NMR)
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Anneke Lubben
mc2@bath.ac.uk
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Biological NMR Facility
NMR spectrometry
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- High-field Nuclear Magnetic Resonance spectrometry
- Protein and small molecule structure analysis
- Protein-ligand binding studies
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Matt Crump
Matt.Crump@bristol.ac.uk
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Animal Behaviour Clinic
Veterinary Services, Animal Welfare
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- Behaviour consultation
- Referring clinical cases
- Residency programme
- Separation related behaviours
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Clinical Behaviour Office
Langford-behaviour@bristol.ac.uk
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